What is MTHFR?

June 7, 2022

Methylene homocysteinetetrahydrofolate reductase is an enzyme that breaks down the amino acids in the body  Amino Acids help the body repair tissue and break down food.  The ability to function normally or completely inactivate it can be interfere with by the MTHFR genes, which have the potential to mutate.

Everyone has two MTHFR genes, one inherited from your mother and one from your father.  Mutations can occur in one or both MTHFR genes.  An MTHFR test looks for two of these mutations, also know as variants.  The MTHFR variants are called C677T and A1298C.  


The simple blood or spit test can help you understand what genetics you are working with.  At Mind Health Connect, we are affiliated with MTHFR Australia and have access to the support of a naturopath, nutritionist who understand this genetic mutation.  This is currently not available in Canada. 


The main symptoms of depression, anxiety and bipolar disorder are often misdiagnosed and treated with anti-depressant and anti-anxiety drugs, even though they don’t always work, and can lead to long-term problems.  In fact, in some cases, they can even make the problem worse.  This is why so many people suffer for years before getting diagnosed.  But by the time they’re finally properly diagnosed, their mental health is already at serious risk.  We are looking to treat the causes of this genetic mutation rather than the results.  The goal is to support the body in absorbing nutrients and to help detoxify.

In Canada, approximately 54% of individuals experience mental health issues.  Often, mental health problems are treated by prescription only.  But at Mind Health Connect, we work to ensure that patients are receiving the best treatment possible.  We offer the right kind of care to our patients, though (should they wish) supportive care with those affiliations that can offer the best expertise.


Living with one of the MTFHR gene mutations will require some changes.  The addition of eating more folate in your diet will help.  Some of the best whole-food sources of folate include dark leafy greens, avocado, and lentils.

Those with an MTFHR mutation ae also at higher risk of being low in Vitamin B12.  Vitamin B12 can be supplemented easily without a prescription, whether isolated B12 or present in multivitamins and B complex vitamins.  Foods high in Vitamin B12 include pastured eggs, nuts, beans, and nutritional yeast.  Additional foods that support healthy methylation include asparagus, avocado, broccoli, and legumes.

Because reduced methylation contributes to poor detoxification, it’s important to support your body’s natural elimination pathways.  In addition to the best probiotics for detoxification, consider taking a quality supplement for supporting detoxification.  A combination of digestive enzymes and an immune support supplement may help with detoxification.

Alcohol intake can make symptoms worse by inhibiting DNA methylation and increasing the demands of detoxification on the liver.  Limiting your consumption of alcohol can support less interference in already stunted methylation processes in those with the MTHFR gene.

Those with MTHFR genetic variations are more likely to have an imbalance of neurotransmitter levels, which can affect mood and irritability, especially when stressed.  In fact, high stress levels can exacerbate MTHFR mutation symptoms.

Healing and supporting your gut is critical to improving methylation and bringing your body back to optimal overall health.


By understanding the causes of some of these mental illnesses, Mind Health Connect will work with you in assisting in your lifestyle changes that will manage your mental health in a positive way.  We will connect you to supportive care both local and international, should you wish, that has been vetted to understand MTHFR.

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